Comparison of the Effect of Injectable Acetaminophen with Injectable Ketamine by Morphine Pump on Reducing Acute Pain after Laparoscopic Cholecystectomy Surgery

Abstract

Majid pourfarokh, Majid Golrezaei, Mitra Azar Aca and Asghar Karbord

Introduction: At the issues that have always been the concern of the surgical team is finding a way to better control post-operative pain, because pain controls a significant role in the length of time the patients stay in the hospital, the level of patient satisfaction, the recovery period and the patient's return to normal life activities. Millions of patients in the world undergo surgery every year, and most of them report unrelieved pain after the surgery.

Aim: To compare the control and reduction of acute pain in patients after laparoscopic gallbladder surgery by injectable acetaminophen and injectable ketamine. Materials and methods: this RCT study, which was conducted as a non-blind randomized clinical trial, 50 laparoscopic gallbladder surgery patients who referred to the teaching hospitals of Qazvin University of Medical Sciences in 2022 were selected as available and as Injectable acetaminophen and injectable ketamine were randomly divided into two drug groups and pain reduction was investigated and analyzed.

Results: this study, the average age group of patients (in two groups) was 49.34 ± 13.52, and the pain reduction in both groups was less in those under 30 years of age, and more pain reduction in those over 30 years old, so that over 50 years of age had the greatest pain reduction, and The reduction of pain in the acetaminophen group was more than that of ketamine and it was statistically significant (P = 0.02). The reduction in pain intensity in the patients in the injectable acetaminophen drug group after receiving the full dose of the drug showed a noticeable and greater decrease compared to the ketamine group. Therefore, injectable acetaminophen was seen as an effective drug in reducing pain after laparo- scopic surgery and it was statistically significant. (P = 0.002).

Conclusion: In this study, the effect of injectable acetaminophen was very effective in reducing the amount of pain and the intensity of pain after laparoscopic surgery, but ketamine not only does not reduce the effect of pain, but it also changes the effect of other.

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