Journal of Gynecology & Reproductive Medicine(JGRM)
ISSN: 2576-2842 | DOI: 10.33140/JGRM
Impact Factor: 1.247
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Clomiphene Citrate Combined with Tamoxifen Citrate versus Letrozole for Inducing Ovulation in Patients with Clomiphene Citrate -Resistant Polycystic Ovary Syndrome
Abstract
Abdelhaseib Salah, Hesham Ammar, Dalia Ibrahim and Heba Maged
This prospective observational study was conducted on 242 patients with clomiphene citrate (CC) resistant polycystic ovary syndrome (PCOS) who were allocated into two regimens of induction of ovulation, the first group(n=128) received both CC and tamoxifen and the second (n=114) received letrozole. The ovulation rate, endometrial thickness, number of dominant follicles, pregnancy rate, miscarriage rate and live birth rate were found comparable between the two groups. Combined therapy with CC and tamoxifen is beneficial in patients with PCOS who failed to respond to CC alone.