Cardio Vascular Disease and its Prevention
Abstract
Purusharth Kumar Sharma
• As it boost or we can say it will catalyze an enzyme called cytochrome p 450 heme enzyme. which is a protein enzyme and heme as co factor and term p 450 explain that the peak level of absorption of wavelength is 450 nm for this enzyme
• This enzyme is primarily present in inner membrane of mitochondria and in endoplasmic reticulum.
• Now this enzyme convert cholesterol in to 7- alpha – hydroxyl cholesterol in such a prominent way or we could say that in such a way that farnesoid X receptor we not able to suppress it.
• And it stops the negative feedback pathway that is establish generally in the human body
• As above stated that this Guggulsterone has two Sterio isomers in which the E sterio isomers is very effective then Z sterio isomer because this E sterio isomer is very stable then Z sterio isomer because of steric effect.