Cancer Screening in Angolan Individuals Using Tumor Marker Tests at MEDIAG, Luanda-Angola

Abstract

Edson Kuatelela Cassinela, Lourenco Quixari, Silvana da Rocha Silveira, Cruz dos Santos Sebastiao, Antonio Armando,Carlos Alberto Pinto de Sousa, Jose Fernando, Manuel Sangombe Epalanga and Euclides Nenga Manuel Sacomboio

Tumor biomarkers have great potential in screening and their role could extend further from general population risk assessment to treatment response estimation and recurrence monitoring. Different molecular and cellular elements in blood, which give information about the status of an individual, make it a perfect compartment to develop noninvasive diagnostics approaches for cancer. The present study aimed to screen the most frequent tumor markers in the Angolan population according to age and gender. A whole blood sample was collected for each patient. Serum levels were measured using the electrochemiluminescence method, using the automated Cobas e411 equipment (Roche®) according to the manufacturer's instructions. The results of our study elucidated the relevance of tumor biomarkers in screening for different types of cancer. These results also highlight the robustness of the mean in suspected cases, which is 15 to 17 times higher in some markers than in non-suspected cases. More research is needed to elucidate the relevance of these biomarkers in the Angolan population.

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