Brown adipose tissue in the form of innovative approach for polycystic ovary syndrome treatment-still long time to reach clinical arena: a narrative review’

Abstract

Kulvinder Kochar Kaur, Gautam Nand Allahbadia and Mandeep Singh

Brown adipose tissue(BAT)portrays a specialized tissue, possessing a crucial part in metabolism as well as energy expenditure(EE) via adaptive non shivering thermogenesis .Recently it has assumed a significant part in the treatment of obesity along with metabolic disease.The thermogenesis action of BAT is brought about by uncoupling protein1 (UCP1 ),that uncouples adenosine triphosphate (ATP) generation from oxidation of energy substrates.Having reviewed earlier various aspects pf Polycystic ovary syndrome (PCOS) pathophysiology,treatment,role in trans generational PCOS transferalong with role of BAT pathophysiology,beige/brite adipocytes in the treatment of obesity along with metabolic disease here we decided to further evaluate the possible part of BAT in PCOS. Thus anarrative review was carried out using the pubmed, Web of Science , Medline, Embase, Cochrane reviews, and Google Scholar, Search engine with the MeSH Terms;PCOS; impaired lipid metabolism; Brown Adipose tissue (BAT); White Adipose tissue(WAT); oxidative stress;inflammation;obesity ;T2DM); Type 1 diabetes (T1D); role of natural substances for PCOStherapy like rutin ,berberine;resveratrol ; weight reduction; browning of WAT ;Macrophage Polarization from 1990 till date in 2023.We found a total of 250 articles ,out of which we selected. 100 articles for this review. No meta-analysis was done. The endocrine action of brown Adipocytes impacts the energy balanceof glucose as well as lipid homeostasis thus impacting the correlation of BAT activity along with metabolic profile. PCOS mirrors a complicated reproductive as well asmetabolic condition of women in their reproductive age. Fcapital aberrations in adipose tissue have been illustrated in PCOS patients. Multiple studies have illustrated that BAT possesses the capacity of controlling the properties of PCOS as well as escalating BAT mass/activity were efficacious in the therapy of PCOS. Via cold stimulation, BAT transplantation as well as activationwith substances like rutin aypoglycemiaX along with as well as

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