Bone Metastases: Epidemiological, Clinical and Therapeutic Aspects

Abstract

Mehdi Toreis, Az Bazine, Y. Touimri and M. Fetohi

Bone is a common metastatic site in many cancers. Bone metastasis is a secondary bone cancer, whose etiologies are dominated by breast cancer (50% of cases), lung, prostate, thyroid, kidney and bladder cancers. The work is part of a retrospective, descriptive and analytical epidemiological study. This study takes into account 40 patients admitted for a period of 02 years, from January 2017 to December 2019, in the medical oncology department at the Moulay Ismail Military Hospital in Meknes. Our study includes 16 women and 24 men, with percentages of 40% and 60% respectively and a sex ratio of 1.5. The mean age of discovery of bone metastases was 60 years with extremes ranging from 28 to 84 years. Bone metastases were inaugural in 5 patients (12.5%). While in the others, they were discovered during the extension workup or during the follow-up of the primary tumor in 37.5% and 50% of the cases respectively. The most frequent primary tumor in our series was prostate cancer in 13 cases (32.5%), followed by breast cancer in 11 cases (27.5%) and lung cancer in 8 cases (20%).The treatment was based on systemic treatments of neoplastic pathology according to the location and histological type of the tumor, associated with biphosphonates. 3 patients (7.5%) received surgical treatment. Antalgic or consolidation radiotherapy was delivered in 15 patients (37.5%). Overall survival calculated by the Kaplan Meier method ranged from 1 to 47 months with an average of 13.5 months.

PDF