Biosafety of Polymethyl Methacrylate as Glaucoma Drainage Plate

Abstract

Virna Dwi Oktariana Asrory, Bambang Soegijono, Ratna Sitompul, Widya Artini, William H. Morgan

This study assesses surface roughness, biomaterial alteration and chemical compound on the polymethylmethacrylate plate of glaucoma drainage device (GDD) pre and 30 days post implantation on rabbit’s eye. The implant’s surface roughness was examined in 2D and 3D by Atomic Force Microscopy (AFM). The biomaterial alteration was assessed by Fourier Transform Infrared Spectroscopy (FTIR). Any tissue adhesion was also assessed since it might affect the result of the examination. Chemical compound was measured by Gas Chromatography Mass Spectrometry (GCMS). In the preimplantation assessment of surface contour, there were some sloping and rising area, but the range of amplitudo was around 28 nm. The feature of the implant in 2D was quite smooth. There were slight roughness changes of the PMMA plate after implantation and the range of amplitudo became around 22.9 nm. The elevation that was seen might be caused by the shape of the implant (curve). The FTIR assessment showed that the wavelength transmission pre and post implantation was relatively similar, which was 98,33% with frequency 3444,41 cm-1 compared to 98,09% with frequency 3445,46 cm-1. It means that there was no polymer degradation. There were some additional compounds found on the implant after surgery, but not a toxic compound.

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