Biomimetic Synthesis of Silver Nanoparticles for Breast Cancer Therapeutics and Its Mechanism

Abstract

Yasmin Khan, Muhammad Qasimnasar, Muhammad Numan, IkramUllah and Zabta Khan Shinwari

Scientists are investigating to find new strategies in the field of nanotechnology for the cure and diagnosis of breast cancer as it is considered as real medical issue for women. Women carrying a pathogenic germline transmutation in BRCA1/2 and has hazard of causing breast cancer because of its high lifetimeand extensive amount of cancer with BRCA1 transmutation which is related with the TNBC phenotype. Nanotechnology is an emerging field which makes best utilization of idle metals like silver, gold, and platinum to combine metallic nanoparticles. Synthesis of nanoparticles using biological system have several benefits over synthetic andphysical synthesis (nontoxic, not expensive, eco-friendly and less energy is require). Use of medicinal plants in the field of nanotechnology is fascinating many more researchers towards the biological synthesis of metallic nanoparticles. Such plants can be considered as the best source of diverse phytochemicals for the synthesis of bio-conjugative silver nanoparticles (AgNPs). In this review, we discuss the synthesis of AgNPs from plant extracts and their proposed mechanism of action on breast cancer cell lines. Moreover, we have thoroughly discussedits cases and achievements accomplishedby the use of biogenic AgNPs as cancer therapeutics agents. It is concluded that biogenic AgNPs can become a potential cancer therapeutics agent in the future.

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