Antidiabetic and Nephroprotective of Emblica Officinalis on Streptozotocin Induced Toxicity in Swiss Albino Mice

Abstract

Pramod Shankar, Arun Kumar, Ranjit Kumar, Mohammad Ali and Sudhir Kumar Srivastava

Diabetes mellitus in the present date has become a major health concern problem in the population worldwide. The drugs available for the medication are very limited and have side effects hence new drug discovery is required. The present study is aimed to investigate the anti- diabetic and antitoxic effects of Emblica officinalis (Amla) fruit extract on Streptozotocin induced diabetic mice.

The study was approved through the Institutional Animal Ethics Committee of the institute. Mice were grouped into 3 groups – Control (n=6), Streptozotocin treated (n=12) and Emblica officinalis administered group (n=6). Treated group mice were administered with Streptozotocin 100 mg/kg body weight intraperitoneally. After the development of diabetes in mice the aqueous fruit, extract of Emblica officinalis at the rate of 100 mg/kg body weight was administered for 4 weeks to evaluate its anti- hyperglycemic activity. There serum glucose levels as well as the Kidney Function Tests (KFT) – urea, uric acid and creatinine levels were analyzed statistically using ANOVA and Dunnett’s tests. In the present study, there was significant increase in the serum glucose levels in the Streptozotocin induced diabetic group in comparison to control group while in the Emblica officinalis group there was significant decrease in the glucose denotes the antidiabetic effect. The KFT showed significant elevation in the levels in Streptozotocin induced groups while the Emblica officinalis showed significant decrease in in the KFT levels denotes the antitoxic effects. Thus, from the entire study it can be concluded that Emblica officinalis can be used as a potent natural anti-diabetic drug, which can control the diabetes at much extent. Furthermore, it also prevents the kidney from the diabetic damage and restores of cellular status of the kidney

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