International Journal of Cancer Research & Therapy(IJCRT)
ISSN: 2476-2377 | DOI: 10.33140/IJCRT
Impact Factor: 1.3
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Anticancer and antimicrobial activities of Imine containing compounds
Abstract
Syeda Uroos Qazi, Asia Naz, Aneela Javed
A series of imine derivatives (3a-m) including thio-semicarbazone, semicarbazone, thiazole and oxazole functional moieties were examined for anti-cancer activity in-vitro by MTT assay using glioblastoma cell line (U87). Among all compound 3m was most potent compound with IC50 value of 8.86 ± 0.15 µM. Cytotoxicity of compounds were evaluated using normal human embryonic kidney cell line i.e HEK-293. Moreover, antibacterial activity of synthesized derivatives was also evaluated by disc diffusion method.