Antibody Levels with Cut off Points of 30 IU/ml blood, 50 IU/ml blood, and 80 IU/ml blood after Employees Administering the Second Dose of the Covid19 Vaccine at Bontang Islamic Hospital (RSIB) in March, May and August 20

Abstract

Windiyaningsih Cicilia, M. Sawali, Atik Kridawati, Erik Sapta Yanuar

Several types of vaccines from the results of phase 3 trials such as mRNA vaccines were developed by American companies, namely Moderna and Pfizer which have been tested for the first time in humans on March 16 2020 in America, Brazil has also been vaccinated with the Sinovac Biotech China covid-19 vaccine in March January 2021 was reported to have an efficacy of 78%, in Turkey 91.25% and in Indonesia 65.3%. The aim of the study was to evaluate antibody (Ab) levels after the second dose of vaccination on day 14, 3 months, 6 months, with cut-off point Ab 30 IU/ml blood; 50 IU/ml of blood and 80 IU/ml of blood after being given the second dose of the covid19 vaccine, as well as factors that influence it such as gender, age and nutritional status. The research method of the Covid19 vaccine intervention study was given two doses, the number of respondents was 93 persons who were selected who had completed the second dose of vaccination and had their antibodies checked on day 14, 3 months and 6 months using the ELISA test method with cut-off point Ab 30 IU/ml blood; 50 IU/ml of blood and 80 IU/ml of blood after being given the second dose of the covid19 vaccine, as well as factors that influence it such as gender, age and nutritional status. The analysis was descriptive and analytic with Chy Square analysis and multinominal logistic regression. Results based on gender the majority were women 58.1%, adult age 92.5%, normal nutritional status 64.5%; 14 days after the second dose of Covid19 vaccination, the Ab level according to the cut-off point is ≥ 30 IU/ml amount 50.5% peoples, titer ≥ 50 IU/ml, the number is 43%; ≥80 IU/ml the number is 31.2%. 3 months Ab ≥ 30IU/ml amount 52.7% ≥ 50IU/ml amount 34.4%, ≥80IU/ml amount 24.7%; 6 months, sex has a significant effect only 6 months after vaccination with levels Ab≥30 IU/ml 66.7%, Ab≥50 IU/ml 50.5%, Ab≥ 80 IU/ml 41.9%peoples. Gender affects Ab levels at 6 months with Ab Cut off Point 30 IU/ml (p value 0.034, OR 0.396.95%CI 0.166-0.941) and Ab50 IU/ml (p value 0.033, OR 0.384.95%CI 0.157-0.936). Nutritional status affected Ab levels on day 14 with an Ab titter of 30IU/ml blood (p value 0.043, OR 2450.95%CI 1021-5880) and at 6 months with an Ab titre of 50IU/ ml blood (p value 0.014, OR 3000, 95% CI 1.233-7.299). The conclusion that BMI has an effect on Ab levels is 50 IU/ml blood, the effect is 8.5%, 6 months the most dominant variable in the formation of antibodies is gender, male good improved Ab days 14, and Female 6 moths was good increased Ab.

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