Angioimmunoblastic T cell Lymphoma: Case Report of a Diagnostic Challenge Presented as a Lymphoproliferative Syndrome

Abstract

Letícia Alves Antunes and André Paternò Castello Dias Carneiro

Angioimmunoblastic T-cell Lymphoma (AITL) is a rare malignancy that only represents 2% of all non-Hodgkin lymphomas, however this is the most common subtype of all the peripheral T-cell Lymphomas (15-20%). Most patients are elderly, and the median patients’ age is around 60-years-old. The most prominent symptoms at the time of presentation are generalized lymphadenopathy, hepatosplenomegaly, fever and weight loss. The clinical presentation may mimic inflammatory, autoimmune and infectious diseases, or even other lymphoid neoplasms. Most of the patients usually have simultaneous extranodal disease in spleen, liver, skin, lungs and bone marrow. The definite diagnosis is usually tricky, and can only be achieved by lymph node biopsy.

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