Anaplastic Meningioma Who Grade III: Case Report and Review of Immunohistopathological Characteristics
Abstract
James Lubuulwa, Kai Shu, Wei Jiang and Ting Lei
Introduction: Anaplastic meningiomas constitute about 2% of all intracranial meningiomas and are known to be aggressive with a mean overall survival and mean relapse-free survival of 3.3 years and 2.7 years respectively. We treated a patient with a World Health Organization (WHO) grade III Anaplastic Meningioma, a rare histological variant of convexity meningiomas in which intraoperatively we found the tumor mass was unique of mixed characteristics particularly peritumoral subdural effusion
Research Question: We show in this case report that convexity lesions presenting with subdural lesions should be highly suspected for WHO III anaplastic meningiomas backed with the immunohistopathological findings.
Material and Methods: Routine computed tomography for patients with neurologic signs and symptoms which reveal a convexity peri-tumoral subdural collection should be suspected for WHO III anaplastic meningiomas. Surgery and adjuvant radiotherapy offered a good clinical outcome.
Results: Postoperative the patient described a gradual improvement of the of expressive aphasia, deficits in speech, detectable personality changes or motor/sensory deficits. MRI at the three-month, six-month, one- year and two-year postoperative follow-up, revealed no evidence of residual tumor nor any observed recurrence nor recurrence of pre-operative symptoms.
Discussion and Conclusion In this paper, we present the rare radiological presentation and immunohistopathological characteristics of this WHO III Grade III anaplastic meningioma. WHO III anaplastic meningiomas should be considered in the differential diagnosis of intracranial tumors which present with peritumoral subdural collection on routine contrast tomography imaging. Our findings may contribute to the literature of the histopathological nature and behavior of this tumor subtype.