Amyloid Plaque and Autism: Exploring the Potential Link and Implications for Treatment
Abstract
Ali Rahmani and Maedeh Dahaghin
Amyloid plaque, a protein aggregate typically associated with Alzheimer's disease, has also been observed in the brains of individuals with autism spectrum disorder (ASD). This has raised questions about a potential connection between amyloid plaque and ASD development. While the significance of this finding is not fully understood, several theories propose mechanisms by which amyloid plaque could contribute to the development of ASD. One theory suggests that amyloid-beta protein, the main component of amyloid plaque, could disrupt normal brain development and function by impairing synaptic formation and maintenance. Another theory posits that the presence of amyloid plaque may be a secondary effect of genetic and environmental factors shared with ASD. Understanding the implications of this potential link is crucial for developing effective treatments for ASD, as current options only address associated symptoms. If amyloid plaque is indeed a contributing factor, targeting its formation or accumulation in the brain could provide a new therapeutic approach. However, further research is needed to fully elucidate the relationship between amyloid plaque and autism and evaluate the feasibility of such treatments. This area of investigation holds promise for advancing our understanding and management of ASD.