Ameliorative Effect of Ferulic Acid against Cyclophosphamide Induced Behavioural and Biochemical Changes in Albino Mice

Abstract

Vinay Kumar, Himani Tyagi, Gauri Goyal, Priyanshi Varshney and Shardendu Kumar Mishra

Background: Cyclophosphamide (CP) is a distinguished anticancer and immune subduing medicament but it has neurotoxicity as a limitation.

Objective: The primary objective of this study was to describe the neuroprotective effects of ferulic acid in contradiction to cyclophosphamide-prompted neurotoxicity in the Swiss Albino mice.

Methodology: Mice were alienated into five groups (n=7) and treated with FA for fourteen days and a single dose of CP was administered on the seventh day. Animals were imperilled to neurobehavioral tests such as Rotarod test, Tail suspension test, and Y-maze test. On day fifteenth, animals were forgone and brain was detached and used for biochemical analysis.

Result: Cyclophosphamide administration likewise condensed the activity of antioxidant enzyme (GSH), and increased lipid peroxidation i.e., malondialdehyde (MDA) and pro-inflammatory cytokines (TNF-α and IL-1β). Furthermore, CP administration amplified the level of acetylcholine esterase (AChE).

Conclusion: The study showed a significant neuroprotective effect of ferulic acid and describe that it can be used as an adjuvant among chemotherapeutically treated patients.

PDF