Acetaminophen: for Its Mechanism of Analgesic Action in Vivo Using Molecular Docking

Abstract

Haider Sami Alaskiry

Paracetamol is the most widely used over-the-counter drug in world. The mechanism of action of its analgesic and antipyretic effect by relying on the association of activation of dopamine D2 receptors through two mechanisms of action. A new metabolic pathway involving the generation of an active metabolite p-aminophenol By being metabolized in the liver by acylamidase/N- deacetylase, and Metabolism of paracetamol to C_6 H_7 NO_2 by its hepatic metabolism CYP2A6. This paper describes the experimental Data that showed the involvement of these two metabolic pathways in analgesic and antipyretic action of paracetamol and its relationship with dopamine D2 receptors “It also explains how new targets and systems play an important role in the action of paracetamol” Finally, treatment strategies for pain and Antipyretic.

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