A Study to Evaluate the Efficacy of Baicapil Formulations in Treatment of Telogen Effluvium

Abstract

Sushruth G Kamoji, Ashwini P and Jayashree Nayak

Introduction: The changes in lifestyle and food habits have resulted in a steady increase in number of people presenting with hair loss and poses quite a challenge for dermatologists. Baicalin is an active flavonoid which activates dermal papilla cells & induces the mRNA expression of growth factors, such as insulin like growth factor 1 (IGF1) and vascular endothelial growth factor (VEGF). This action can clinically transform the telogen phase to anagen phase due to which there is good scope of using this product in telogen effluvium.

Materials & Methods: This was a pilot study on 30 subjects who had persistent hair loss for more than 3 months. Subjects were directed to apply 1ml (6 sprays) of the anti hair loss serum containing Baicapil in the morning after bath & once before bed time for 2 months. Efficacy of the hair serum was assessed using subjective scale and objective method at baseline, day 30 and day 60.

Results: In our study 63.3% of subjects had persistent hair loss of more than 6 months duration. Majority of our subjects belonged to the age group of 21 to 25 years with mean age of 26.33 ± 8.7 years and 46.7% were students. In the study median subjective score at 1st visit was 7, at 2nd visit score reduced to 6 and at 60th day score reduced to 4 which is statistically significant (p=<0.001). With respect to objective assessment at Point A, median number of thin hairs at 1st visit was 6, at 2nd visit it reduced to 4 and at 3rd visit reduced to 3. With respect to Objective assessment in Point B, median number of thin hairs at 1st visit was 5, at 2nd visit reduced to 3 and at 3rd visit reduced to 2 which was also statistically significant(p=<0.001).

Conclusion: Baicapil formulations are effective in decreasing hair loss and promoting hair growth in case of patients with telogen effluvium.

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