A Case of COVID mRNA Vaccine Linked Antiphospholipid Syndrome

Abstract

E.J. Balbona

There have been several reports of thrombotic adverse events after administration of the mRNA Covid vaccine [1, 2]. The onset of autoimmune disease has also been reported following viral illness as well as following vaccination [3]. Anti- phospholipid syndrome (APS) is an autoimmune hypercoagula- ble state that can result in thrombotic events such as deep venous thrombosis, pulmonary embolus, and stroke [4]. Antiphospho- lipid antibodies (aPLs) are associated with APS syndrome. How- ever, not all individuals with aPLs will develop antiphospholipid syndrome as antiphospholipid antibodies are also present in up to 5% of the healthy population. Antiphospholipid antibodies have been reported after infections and vaccines. Antiphospho- lipid syndrome has also been reported following natural Covid infection [5]. Herein we present a case of antiphospholipid syndrome following Covid mRNA vaccination associated with life-threatening thrombosis, dyspnea, and hypoxia coupled with multiple adverse reactions affecting skin, respiratory, nervous, and vascular systems.

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