Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular.  Drug addiction is a chronically relapsing disorder that has been characterized by the compulsive use of addictive substances despite adverse consequences to the individual and society. Addiction to drugs and alcohol is increasingly becoming a worldwide trend in lifestyle that is prevalent in rich and poor countries alike. Addiction to alcohol, drugs and cigarette smoking is now regarded as a major public health problem. Other forms of addiction including computer games, gambling, sex and food also have severe consequences on the health of the individual and to society. The commonly abused drugs have profound action in the nervous system, particularly in the brain. Some of these substances such as opium, marijuana, cocaine, nicotine, caffeine, mescaline, and psilocybin are obtained from natural sources while others are synthetic or designer drugs.