Nucleosides have played a consequential role in the treatment of viral diseases. The treatment of human immunodeficiency virus (HIV) infection has visually perceived the exordium of no less than eight nucleos(t)ides into clinical practice where they have become the cornerstone of coalescence therapies. Nucleos(t )ides have become the standard of care for the treatment of hepatitis B virus (HBV) infection and are expeditiously emerging as the backbone of future amalgamation regimens for the treatment of hepatitis C virus (HCV) infection. The treatment of many other viral infections such as those caused by cytomegalovirus, herpes simplex virus, Epstein virus, and varicella zoster virus rely heavily on nucleos(t)ide-predicated therapies. Consequently, because of the broad utility and prosperity of these molecules in the treatment of viral diseases, efforts perpetuate to probe for novel nucleos(t)ides that can have an impact in antiviral clinical practice. This review will fixate on recent developments in the field of nucleos(t)ide antiviral drug revelation and development with accentuation on HIV, HBV, HCV, and Dengue virus.

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