Developing incipient methods for chemotherapy drug distribution has become a topic of great concern. Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however, their side effects are concretely problematic for many medical medicos. To truncate the toxicity and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies such as utilizing liposome-entrapped drugs, chemical- or peptide-modified drugs, polymeric packaging drugs, and chemotherapy drug coalescences. This review mainly fixates on the development of a vinca alkaloid drug distribution system and the amalgamation therapy. All the data engendered from the study will be stored in an anonymized form in a database, which will additionally be password bulwarked. Only anonymized information will be stored on this, and participants will only be identifiable by their study number. All paperwork will be kept in a locked filing cabinet in a locked office. All data will be stored on a password-forfended computer with constrained access to the research team. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. Impact factor plays a major role for the particular journal.