Tumor necrosis is often limited to a small area within the sample. Its presence suggests a more aggressive breast cancer. Hypoxia is a marker of more aggressive tumors and tumor necrosis was significantly associated with features such as high histologic grade, vascular invasion by tumor cells and reduced survival. Tumor necrosis was defined as areas of necrotic tumor cells immediately adjacent to viable tumor tissue .Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse cellular events such as cell survival, proliferation, differentiation, and death. As a pro-inflammatory cytokine, TNF is secreted by inflammatory cells, which may be involved in inflammation-associated carcinogenesis. A malignant wound can result from tumor necrosis, fungating tumor cells, an ulcerating cancerous wound, or a malignant cutaneous wound.  One of multiple proteins capable of inducing necrosis (death) of tumor cells that possess a wide range of proinflammatory actions.Because most tumor cells are genetically limited in apoptotic pathways and prone to necrotic cell death. Tumour necrosis factor (TNF), a naturally occurring protein that is produced in the human body by the phagocytic cells known as macrophages. The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. The tumor necrosis factor (TNF) superfamily, composed of 19 ligands and 29 receptors, plays highly diversified roles in the body.