Transsexual individuals experience a sexual orientation personality that is conflicting with their appointed sex, and want to forever progress to the sex or sex with which they recognize, normally looking for clinical help (counting sex reassignment treatments, for example, hormone substitution treatment and sex reassignment medical procedure) to assist them with adjusting their body to their distinguished sex or sex.

Transsexual is a subset of transgender; however some transsexual individuals dismiss the mark of transgender. A clinical analysis of sex dysphoria can be made if an individual communicates a craving to live and be acknowledged as an individual from their recognized sex and if an individual encounters hindered working or trouble because of their sexual orientation personality.

Since the center of the twentieth century, gay transsexual and related terms were utilized to name people's sexual direction dependent on their introduction to the world sex. Many sources censure this decision of wording as befuddling, "heterosexist", "archaic", and belittling since it marks individuals by sex doled out during childbirth rather than their sex identity. Sexologist John Bancroft additionally as of late communicated lament for having utilized this phrasing, which was standard when he utilized it, to allude to transsexual women. He says that he currently attempts to pick his words all the more delicately.