Toxic kinetics is defined as the passage through the body of a toxic agent or its metabolites ,Toxicokinetics is the study of systemic exposure during toxicological experiments. The objective is to quantify the systemic exposure and potentially relate that to toxicology findings. The comparison of toxicology exposure parameters to therapeutically effective exposure parameters gives rise to the idea of a therapeutic window, or the space between efficacy and toxicity. This is depicted in a theoretical example below. Open access to the scientific literature means the removal of barriers (including price barriers) from accessing scholarly work. There are two parallel “roads” towards open access: Open Access articles and self-archiving. Open Access articles are immediately, freely available on their Web site, a model mostly funded by charges paid by the author (usually through a research grant). The alternative for a researcher is “self-archiving” (i.e., to publish in a traditional journal, where only subscribers have immediate access, but to make the article available on their personal and/or institutional Web sites (including so-called repositories or archives)), which is a practice allowed by many scholarly journals.