In Silico Biology (ISB) was founded in 1998 as a purely online journal. IOS Press became the publisher of the printed journal shortly after. Today, ISB is dedicated exclusively to biological systems modeling and multi-scale simulations and is published solely by IOS Press Silico Biology is a logical examination diary for the headway of computational models and reproductions applied to complex natural wonders. We distribute peer-explored driving edge organic, biomedical and biotechnological research in which PC based (i.e., "in silico") displaying and examination devices are created and used to anticipate and explain elements of natural frameworks, their plan and control, and their development. Trial backing may likewise be given to help the computational investigations. In Silico Biology plans to propel the information on the standards of association of living frameworks. We endeavor to give computational structures to seeing how detectable natural properties emerge from complex frameworks. Specifically, we look for integrative formalisms to interpret cross-talks fundamental frameworks level properties, extreme point of multi-scale models. Studies distributed In Silico Biology by and large utilize hypothetical models and computational investigation to increase quantitative bits of knowledge into administrative procedures and systems, cell physiology and morphology, tissue elements and organ frameworks. Uncommon zones of intrigue incorporate sign transduction and data preparing, quality articulation and quality administrative systems, digestion, multiplication, separation and morphogenesis, among others, and the utilization of multi-scale displaying to interface sub-atomic and cell frameworks to the degree of life forms and populaces.