Several ancient diseases that even exist or of which case reports could be found are Gout, Yellow Fever, Tetanus, Pneumococcal disease, Measles, Pertussis, Diphtheria, Chickenpox, Poliomyelitis, Leishmaniasis, Cholera, Lyme disease, Inanition, Ergotism, Pharyngitis, Smallpox, Trachoma, Leprosy, Typhoid fever, Plague, Neuralgia etc. A disease is an abnormal condition affecting a living organism. Diseases are generally understood to be medical conditions that involve a pathological process associated with a specific set of symptoms. Localized diseases affect specific parts of the body; disseminated diseases spread to other parts of the body; and systemic diseases affect the entire body. Each disease process has an origin, or etiology, but some diseases may present with different or confusing symptoms, making them difficult to diagnose or determine. The information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal. Journal with higher impact factor is considered to be more important than other ones.