Several ancient diseases that even exist or of that case reports may well be found are gouty arthritis, black vomit, Tetanus, diplococcus malady, Measles, Pertussis, Diphtheria, Chickenpox, polio, protozoal infection, Cholera, zoonosis, Inanition, Ergotism, raw throat, Smallpox, Trachoma, Leprosy, typhoid, Plague, pain etc. A malady is associate degree abnormalcy poignant a living organism. Diseases square measure usually understood to be medical conditions that involve a organic process related to a selected set of symptoms. Localized diseases have an effect on specific components of the body; disseminated diseases unfold to alternative components of the body; and general diseases have an effect on the complete body. Every malady method has associate degree origin, or etiology, however some diseases might gift with totally different or confusing symptoms, creating them tough to diagnose or confirm. The information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal. Journal with higher impact factor is considered to be more important than other ones.