Tissue engineering has been recognized as a change of location approach to interchange broken tissue or whole organs. Engineering tissue, however, faces an impressive data gap within the challenge to completely recapitulate complicated organ-specific options. Major elements, like cells, matrix, and design, should every be rigorously controlled to engineer tissue-specific structure and performance that mimics what's found. Here we tend to review totally different ways to engineer tissue, and discuss essential challenges in recapitulating the distinctive options and practical units in four major organs—the urinary organ, liver, heart, and lung, that also are the highest four candidates for organ transplantation within the USA. we tend to highlight advances in tissue engineering approaches to modify the regeneration of complicated tissue and organ substitutes, and supply tissue-specific models for drug testing and sickness modeling. we tend to discuss this challenges and future views toward engineering human tissue models. When tissues or organs are therefore severely pathologic or lost by cancer, congenital abnormality, or trauma that typical pharmaceutical treatments are not any a lot of applicable, artificial organs or organ transplantation are the primary option to reconstruct the ravaged tissues or organs. However, these surgical treatments are facing variety of challenges at moment. Artificial organs are improved by exceptional advances within the medicine engineering within the past decades, however still want higher biocompatibility and bifunctionality. issues in current organ transplantation embody shortage of given organs and immune rejection, though immunological disorder medical aid has recently abundant advanced.