The utilization of tissue engineering in the regeneration of craniofacial bone structures is a great challenge. The procedures utilized for reconstruction of craniofacial bone are mostly predicated on autologous, allogeneic, or alloplastic grafting sources with variable clinical outcomes and morbidities. Bone regeneration is an intricate, well-coordinated physiological process. Immensely colossal quantities of bone regeneration are often required for craniofacial skeletal reconstruction of astronomically immense bone defects engendered by trauma, tumor resection, infection, and skeletal abnormalities. Over the last two decenniums, a tissue engineering and regeneration approach has been developed as an alternative to conventional surgical treatments utilizing bone grafts. Tissue engineering methods have several advantages including the potential to regenerate bone with natural form and function. This review presents several key elements of tissue engineering for craniofacial bone: the signaling molecules proteins and genes; scaffolds or fortifying matrices; and cells. Furthermore, the advantages, challenges, and jeopardizes cognate with each element will be discussed. The journals provide forum and incentivizes scientists, researchers, academics, engineers, and practitioners in all aspects to apportion their professional and academic cognizance in the fields computing, engineering, humanities, economics, convivial sciences, management, medical science, and cognate disciplines. Online Journals withal aims to reach an immensely colossal number of readers ecumenical with pristine and current research work consummated on the vital issues of the above paramount disciplines. The journals sanction all readers to read, view, download and print the full-text of all published articles without any subscription or restrictions. To increment the overtness and facilitate of avail of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving accommodations. Indexing provides facile access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. The citations are consequential for a journal to get impact factor. Impact factor is a quantification reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more paramount than those with lower ones. Indexing provides facile access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, pertinent and reliable information predicated on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated utilizing citations not only from research articles but additionally editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and endeavor to increment their number expeditiously. Impact factor plays a major role for the particular journal. Tissue engineering for craniofacial bone is peer reviewed journals works to publish most reliable and consummate source of information regarding advance revelations and development in the path of tissue engineering for craniofacial bone.