Thyroid nodules are common entities, frequently discovered in clinical practice, either during physical examination, but also incidentally, during various imaging procedures. They are clinically important primarily due to their malignant potential. For this reason the initial evaluation should always include a history and physical examination focusing on features suggestive of malignancy. Serum thyrotropin (TSH) and thyroid ultrasonography (US) are pivotal in the evaluation of thyroid nodules, as they provide important information regarding thyroid nodule functionality and the presence of features suspicious for malignancy, respectively. Fine needle aspiration (FNA) biopsy is the most accurate and reliable tool for diagnosing thyroid malignancy and selecting candidates for surgery, particularly if performed under ultrasound guidance.

Perchlorate Contamination of Drinking Water on Thyroid Health ... HER-2 correlated with tumor size only on univariate analysis. OS did ... It has high predictive value, reproducibility, and improved clinical significance.