Deficiency of thyroid hormones ends in thyroid problems both hypo or hyperthyroidism signs and symptoms consists of immoderate fatigue, sweating profusely, intolerance to warmth, rapid coronary heart charge, attention hassle, mild tremor within the limbs, irregular menstrual cycle, unexplained weight loss, dry pores and skin, repeated bouts of constipation, feeling bloodless all the time, despair, excessive fatigue, bloating or fluid retention within the frame. Sever hypercalcemia is by using definition, Calcium degree above 14 mg/dl regardless of the symptoms and it requires instantaneous intervention .Standard of care is hydration, calcitonin, and bisphosphonate .Calcitonin is expected to lower the calcium over 12 to forty eight hours and pamidronate or zoledronic Acid are predicted to dite 48 hours.Нe cutting-edge remedy calls for hospital admission commonly for the intravenous fluid administration and the bisphosphonate infusion. Parathyroid adenoma is the mostcommon reason of number one hyperparathyroidism and hyper calcemia in an outpatient placing. Нe treatment of parathyroid adenoma with sever hypercalcemia is surgical elimination of the parathyroid adenoma Dіet dealing with the instantaneous hypercalcemia.