journal is aimed at everyone working in the modelling and discovery of emergent properties in complex biological systems. Also, it seeks scientists relating the structure and dynamics of living organisms with their physiology and phenotypic traits for the understanding of the whole. In addition to the highest-quality original articles covering the entire field, each issue includes timely reviews of key primary research papers and topics in Systems Biology. Also, the Editors seek the publication of reports on emerging trends in the integration of theoretical models, computational analysis and empirical data, as a framework for understanding any scale of biological organisation, ranging from single cells to ecological systems. The Editorial Committee actively pursues to be a leading source of essential knowledge through promoting excellence and advancement in Systems Biology, Quantitative and Predictive Physiology, and Medicine. The journal encourages original research, expert review of Systems Biology at the forefront of a more holistic approach to understanding the dynamic and complex nature of living systems better. Also, provides insight into system-level approaches of biological research, while potentiating a transformation in the approach to the investigation of fundamental and broader biological systems.