Adenocarcinoma of the anal canal is a rare neoplasm. Worldwide, the incidence is only some thousand cases according to yr. Histologically, it represents about sixteen.5% of all forms of anal canal cancers, which is ruled through squamous cellular carcinoma [1]. The anal canal extends from the anal margin to the anorectal ring/flexure representing the terminal a part of the gastrointestinal tract. Anatomically, based totally on the lining epithelium, the anal canal may be divided into the colorectal quarter described by means of the colorectal sort of glandular mucosa proximally, the anal transition region defined by the variable look of the liner epithelium in the center, and the distal component lined by means of squamous epithelium [1, 2].Several proposals have been made as to the pathologic mechanisms main to the anal canal adenocarcinomas (AA). These encompass anal glandular carcinomas originating from the anal glands, colloid carcinomas related to Paget’s ailment of the anus, and adenocarcinomas bobbing up from chronic fistula and inflammatory epithelium in the anus, as well as adenocarcinomas that arose from the distal rectum with extension into the anal canal [3, 4]. Previous observations that these malignancies have been associated with continual intestinal sicknesses inclusive of preexisting fistulas or Crohn’s disorder induced the speculation for the pathologic improvement of adenocarcinoma of the anal canal [3]