Focal sensory system is one of the mind boggling frameworks in the body which comprises of cerebrum and spinal line. Any ailment or horrendous ambush may prompt the degeneration of CNS including loss of homeostasis [1]. CNS wounds comprise a significant reason for dismalness and mortality incorporate the dangerous wounds, for example, awful mind injury (TBI) and spinal rope injury (SCI) [2–4]. TBI and SCI are brought about by both essential and auxiliary wounds affecting the falls of cell and atomic occasions which will bring on additional harm in the framework and loss of body capacities. The outcomes of the optional injury incorporate mitochondrial brokenness, synapse aggregation, blood-cerebrum boundary (BBB) and blood spinal line obstruction disturbance, apoptosis, excitotoxic harm, inception of provocative, and safe procedures which is trailed by starting essential mechanical injury [5, 6]. Optional injury includes the creation of profoundly responsive species, receptive oxygen species (ROS), receptive nitrogen species (RNS), or free radicals which will make harm protein structure, DNA, and cell film and prompts oxidative pressure which assumes a significant job in the pathophysiology of CNS injury. The movement of the harm begins from the essential effect on mind or spinal line and will proceed for quite a long time, days, and weeks after the underlying mechanical affront which will bring about tissue harm. This audit where two models of CNS injury will be secured will investigate the job of responsive oxygen species (ROS) and momentums inquire about on restorative job of melatonin utilized in the treatment of TBI and SCI.