Hypoactive sexual desire disorder (HSDD) and sexual aversion disorder (SAD) affect both men and women. Despite their prevalence, these disorders are often not addressed by healthcare providers or patients due to their private and awkward nature. Using the Sexual Response Cycle as the model of the physiological changes of humans during sexual stimulation and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSMIV-TR), this article will review the current literature on the two desire disorders, focusing on prevalence, etiology, and treatment. With this knowledge, hopefully, physicians will move beyond their unease with the topic in order to adequately address patients’ sexual problems and to implement appropriate treatment.