Pakistan is perceived as a high risk low prevalence country in relation to HIV/AIDS virus and the indication is that there is a rise in HIV/AIDS cases in the high risk groups with concentrated epidemics beginning in marginalized population like the intravenous drug users in Karachi, which have a high potential of being passed onto the general population due to a closely weaved social network. Pakistani women are more vulnerable to HIV/AIDS infection due to biological and socio-economic factors, especially gender inequality. Since women in the country in general have lower socio-economic status, less mobility and lack of decision-making power, all of these factors further contribute to their HIV vulnerability.