Immunodeficiency or immune compromise is a state wherein the invulnerable framework's capacity to battle irresistible ailment and malignancy is undermined or completely missing. Most instances of immunodeficiency are gained ("optional") because of extraneous variables that influence the patient's invulnerable framework. Instances of these outward factors incorporate HIV contamination and natural components, for example, nutrition. In the clinical setting, the immunosuppression by certain medications, for example, steroids can be either an unfavorable impact or the planned reason for the treatment. Instances of such use are in organ transplant medical procedure as an enemy of dismissal measure and in patients experiencing an overactive insusceptible framework, as in immune system illnesses. A few people are brought into the world with natural imperfections in their resistant framework, or essential immunodeficiency. An individual who has an immunodeficiency of any sort is supposed to be immune compromised. An immune compromised individual might be especially defenseless against crafty contaminations, notwithstanding typical diseases that could influence everyone. Immunodeficiency additionally diminishes malignant growth immune surveillance, in which the safe framework examines the body's cells and kills neoplastic ones. Distinction between essential versus optional immune deficiencies depend on, separately, regardless of whether the reason starts in the invulnerable framework itself or is, thusly, because of inadequacy of a supporting segment of it or an outer diminishing element of it. Scientific journals on immunodeficiency are top open access journals, and this journal has been successfully publishing quality research articles from many years and looking forward to frame up an eminent, outstanding issue with best quality research articles in this year. We request you to kindly submit and publish your paper in the best journal and get global acknowledgment.