In depression or anxiety, exercise often seems like the last thing you want to do. But once you get motivated, exercise can make a big difference. Exercise helps prevent and improve a number of health problems, including high blood pressure, diabetes, and arthritis. Research on depression, anxiety, and exercise shows that the psychological and physical benefits of exercise can also help improve mood and reduce anxiety. Regular exercise may help ease depression and anxiety by Releasing feel-good endorphins, natural cannabis-like brain chemicals (endogenous cannabinoids) and other natural brain chemicals that can enhance your sense of well-being, Taking your mind off worries so you can get away from the cycle of negative thoughts that feed depression and anxiety, etc.