Proteomics primarily could be a subdiscipline of functional genomics that measures the qualitative and quantitative changes in protein content of a cell or tissue in response to treatment or disease and determines protein–protein interactions. As a complementary approach to mRNA expression technologies, proteomics more and more is being applied to drug discovery process. The pharmaceutical trade has expressed important interest in proteomics, with the expectation that this technology can result in the identification and validation of protein targets and, finally to the invention and development of effective drug candidates. Proteomics are divided as two main areas i.e. (i) Expression Proteomics, (ii) Functional Proteomics. The role of Expression Proteomics is the Analysis of various protein expressions by protein quantitation and identification. This protein analysis compares the expression profile of proteomes of cells, tissues or organisms in any condition of health problem, disease, injury, treatment, or intoxication to a standard proteome. Functional proteomics explains about the normal and abnormal interactions of proteins. Isolation of protein complexes include Gene transcription, protein degradation, signal transduction, and cell cycle regulation to be done by multi protein complexes. The information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal. Journal with higher impact factor is considered to be more important than other ones.