Primary rhabdoid tumor of lung is a rare histological and clinical entity. Lung tumors with rhabdoid features have been included as variants of large-cell carcinoma in the 1999 World Health Organization (WHO) classification of lung tumors. A large-cell carcinoma with a rhabdoid phenotype (LCCRP) is unusual, with only 38 cases reported till date. We report the clinical details of one such case that was treated with pneumonectomy and adjuvant chemotherapy. We also present a review of the literature.

Endometrial carcinoma (EC) and ovarian carcinoma (OvCa) are two common female cancers, accounting for 4th and 5th-leading causes of cancer death among women in the United States (Siegel, Miller & Jemal, 2019). EC can be divided into two subgroups, a type I endometrioid tumors and a type II serous-like tumor (Getz et al., 2013). Compared to type I EC, type II serous-like EC was characterized with a more advanced stage and worse outcome. As for ovarian cancers, high grade OvCa serous tumors account for the most cancer death (Matulonis et al., 2016). Previous studies have identified similar genetic aberrations among serous-like EC and serous OvCa (Getz et al., 2013). For example, both serous-like EC and serous OvCa have frequent TP53 mutation, whereas type I endometroid EC does not. Also, serous-like EC and serous OvCa are both featured with chromosome instability and copy number alteration (CNA), compared to very few CNA events in type I endometroid EC. These findings suggest that they might be caused by similar oncogenic drivers and more importantly, share common molecular mechanisms for tumor progression.