Ischaemia-Reperfusion injury (IRI) is characterized as the confusing fuel of cell brokenness and passing, after rebuilding of blood stream to already ischaemic tissues. Restoration of blood stream is basic to rescue ischaemic tissues. Anyway reperfusion itself incomprehensibly brings on additional harm, undermining capacity and practicality of the organ. IRI happens in a wide scope of organs including the heart, lung, kidney, gut, skeletal muscle and cerebrum and may include the ischaemic organ itself as well as prompt foundational harm to inaccessible organs, conceivably prompting multi-framework organ disappointment. Reperfusion injury is a multi-factorial procedure bringing about broad tissue annihilation. The point of this audit is to sum up these atomic and cell components and therefore give an understanding into potential windows for viable helpful mediation