Endoscopic retrograde cholangiopancreatography (ERCP) is a crucial diagnostic and therapeutic modality in patients with suspected biliary and pancreatic diseases. The diagnostic and therapeutic success of ERCP depends on variety of things including the disease entities being treated, availability of the multiple endoscopic accessories, well trained support staff and therefore the endoscopist’s skill and knowledge . Successful cannulation of the choledochus represents the foremost significant step of the diagnostic and therapeutic procedures. Cannulation procedure is reported to realize a hit rate of 80-95% when performed by experienced endoscopists. In cases where selective cannulation isn't feasible, generally precut papillotomy techniques are performed. However, various complications including pancreatitis, perforation and bleeding are more common upon the utilization of precut techniques. to scale back the ERCP-associated complication risk, it’s important to possess an experienced endoscopist, avoid unnecessary procedures, make adequate preparation before the procedure and operate cautiously.