Gastric outlet obstruction (GOO) is a blockage of the path from the stomach to the small intestines. It may completely block of the path or allow a small amount to pass. The blockage can cause pain and stop food from being digested. The most common cause of motility disorders is gastroparesis, which can result from long-term diabetes, viral damage or from an unknown drug or origin (idiopathic). The incidence of GOO is not known with precision. It is likely to have decreased in recent years because of the decline of peptic ulcer disease-which historically has been a major cause of GOO-as a result of the identification of Helicobacter pylori (H. pylori) and the use of proton pump inhibitors. The primary symptom is vomiting, which typically occurs after meals, of undigested food devoid of any bile. Treatment of the condition depends upon the underlying cause; it can involve antibiotic treatment when Helicobacter pylori is related to an ulcer, endoscopic therapies, other medical therapies, or surgery to resolve the obstruction.