A proto-oncogene is a normal gene found in the cell. There are many proto-oncogenes. Each one is responsible for making a protein involved in cell growth, division, and other processes in the cell. Most of the time, these genes work the way they are supposed to, but sometimes things go wrong. There are trillions of living cells in the body that grow, divide, and die in an orderly fashion. This process is tightly regulated by the genes within a cell’s nucleus. These genes code for proteins that help regulate cell growth. These important genes are called proto-oncogenes. A change in the DNA sequence of the proto-oncogene gives rise to an oncogene, which produces a different protein and interferes with normal cell regulation. Proto-oncogenes have many functions in a cell but they often code for proteins that stimulate cell division, prevent cell differentiation or regulate programmed cell death (apoptosis). These are all essential processes required for normal growth, development and the maintenance of healthy organs and tissues. However, a mutated or defective version of a proto-oncogene (oncogene) increases the production of these proteins, thereby leading to unregulated cell division, a slower rate of cell differentiation and increased inhibition of cell death. Together, these features define cells that have become cancerous. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports.