Protein folding is the physical procedure by which a protein chain procures its local 3-dimensional structure, an adaptation that is typically naturally practical, in a quick and reproducible way. It is the physical procedure by which a polypeptide folds into its trademark and practical three-dimensional structure from an irregular curl. Every protein exists as an unfurled polypeptide or arbitrary loop when interpreted from a grouping of mRNA to a direct chain of amino acids. This polypeptide does not have any steady (durable) three-dimensional structure (the left hand side of the main figure). As the polypeptide chain is being integrated by a ribosome, the direct chain starts to overlay into its three-dimensional structure. Collapsing starts to happen in any event, during interpretation of the polypeptide chain.