Protein–protein interactions (PPIs) area unit the physical contacts of high specificity established between 2 or a lot of macromolecule molecules as a results of organic chemistry events steered by interactions that embody static forces, chemical element bonding and also the hydrophobic result. several area unit physical contacts with molecular associations between chains that occur in an exceedingly cell or in an exceedingly living organism in an exceedingly specific biomolecular context.
Proteins seldom act alone as their functions tend to be regulated. several molecular processes at intervals a cell area unit administered by molecular machines that area unit engineered from varied macromolecule parts organized by their PPIs. These interactions compose the alleged interactomics of the organism, whereas aberrant PPIs area unit the premise of multiple aggregation-related diseases, like Creutzfeldt–Jakob, presenile dementia diseases.
PPIs are studied with several strategies and from completely different perspectives: organic chemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this data permits the creation of huge macromolecule interaction networks – kind of like metabolic or genetic/epigenetic networks – that empower this information on organic chemistry cascades and molecular etiology of malady, still because the discovery of supposed macromolecule targets of therapeutic interest.

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