Fever likewise alluded to as pyrexia, is characterized as having a temperature over the ordinary range because of an expansion in the internal heat level's set point.[ There is anything but a solitary settled upon furthest breaking point for ordinary temperature with sources utilizing values somewhere in the range of 37.2 and 38.3 °C (99.0 and 100.9 °F) in humans. The expansion in set-point triggers expanded muscle withdrawals and causes a sentiment of cold. These outcomes in more noteworthy warmth creation and endeavors to ration heat. When the setpoint temperature comes back to ordinary, an individual feels hot, gets flushed, and may start to sweat. Rarely a fever may trigger a febrile seizure, with this being increasingly basic in youthful children. Fevers don't commonly go higher than 41 to 42 °C (105.8 to 107.6 °F). A fever can be brought about by numerous ailments going from non-genuine to life-threatening. This incorporates viral, bacterial, and parasitic contaminations, for example, flu, the basic cold, meningitis, urinary tract contaminations, an infected appendix, COVID-19, and malaria. Non-irresistible causes incorporate vasculitis, profound vein apoplexy, connective tissue ailment, symptoms of medicine, and cancer. It varies from hyperthermia, in that hyperthermia is an expansion in internal heat level over the temperature setpoint, because of either a lot of warmth creation or insufficient warmth loss. Medications, for example, ibuprofen or paracetamol (acetaminophen) may help with this just as lower temperatures. Measures, for example, getting into a cool sodden material the temple and having a marginally steaming shower are not helpful and may basically make an individual more uncomfortable.  Prolonged fever online journals are top journals. Prolonged fever was defined as fever for at least 14 days and no diagnosis at the time of referral for evaluation, and it has been successfully publishing quality research articles for many years and looking forward to framing up an eminent, outstanding issue with best quality research articles in this year. We request you to kindly submit and publish your paper in the best journal and get global acknowledgment.