The objective of this study is to work out the acceptance of Problem Based Learning (PBL) among medical students. Material and Methods: This study was conducted among 350 Medical students at the Management and Science University (MS

U), Malaysia, during the tutorial year 2011-2012. A cross sectional study was administered among first, second, third and fourth year medical students. Students were explained the target of the study and were invited to participate. Informed verbal consent to participate was obtained and every one participants were assured. Data obtained were analyzed using SPSS version 13. T-test and ANOVA test which were conducted to work out if there was a big difference between the study parameters. Multiple linear regressions were utilized in statistical method . Results: the bulk of the surveyed students were older than, or equal, to 22 years old, Malays, from year 2, with Cumulative mark Average (CGPA) quite 3.3 and family monthly income but 10,000 Malaysian ringgits (60.3%, 52.3%, 44.0%, 37.1%, 85.4% respectively). Race, year and CGPA were found to be significantly related to PBL acceptance among medical students (p = 0.001, p = 0.003, p = 0.003; respectively). Overall, the acceptance of PBL among medical students was quite low (39.7%). In statistical method , age and race were significantly related to PBL acceptance. Conclusion: The acceptance of PBL among the surveyed medical students was low. this means that more rigorous and practical training should tend to tutors and students so as to know the philosophy of PBL.