Pregabalin in the treatment of neuropathic pain, incisional pain, aches and inflammatory pain induced by formalin has been used effectively. Open access to the scientific literature means the removal of barriers (including price barriers) from accessing scholarly work. Effect of pregabalin on sleep architecture: data from a healthy volunteer population. Even though the study subjects were normal volunteers with no sleep complaints, treatment with pregabalin and alprazolam both resulted in significant increases in total sleep time and improvement in sleep efficiency. Pregabalin is structurally related to gabapentin and has a similar pharmacological profile and anticonvulsant and analgesic activity