Malaria is caused by the protozoan parasite Plasmodium. Human malaria is caused by four different species of Plasmodium: P. falciparum, P. malariae, P. ovale and P. vivax.Humans occasionally become infected with Plasmodium species that normally infect animals, such as P. knowlesi. As yet, there are no reports of human-mosquito human transmission of such “zoonotic” forms of malaria.The malaria parasite is transmitted by female Anopheles mosquitoes, which bite mainly between dusk and dawn.alciparum malaria: The most dangerous type of malaria, which is caused by the parasite Plasmodium falciparum. Falciparum malaria is associated with high levels of parasites in the blood and has the highest death rate and rate of complications of all types of malaria. Red blood cells that are infected with the parasite tend to sludge and lead to microinfarctions (tiny areas of dead tissue due to lack of oxygen) in capillaries in the brain, liver, adrenal gland, intestinal tract, kidneys, lungs, and other organs. Patients should be treated in a hospital setting, using intravenous medications.